Abstract
A new cyclic diarylheptanoid, acerogenin M (1), has been isolated along with nine known diarylheptanoids, 2-10, and two known phenolic compounds, 11 and 12, from a MeOH extract of the stem bark of Acer nikoense MAXIM. (Aceraceae). The structure of 1 was determined on the basis of a spectroscopic method. Upon evaluation of the inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation (1 microg/ear) in mice of nine of the compounds (2-6, 8, 10-12), six (2, 4-6, 8, 10) showed a marked anti-inflammatory effect with a 50% inhibitory dose (ID(50)) of 0.26-0.81 mg per ear. In addition, upon an evaluation against the Epstein-Barr virus early antigen (EBV-EA) activation induced by TPA for all of the compounds, all exhibited moderate inhibitory effects against EBV-EA induction (IC(50) values of 356-534 mol ratio/32 pmol TPA).
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Acer / chemistry*
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Animals
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Anti-Inflammatory Agents, Non-Steroidal / chemistry*
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Anti-Inflammatory Agents, Non-Steroidal / pharmacology*
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Anticarcinogenic Agents / chemistry*
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Anticarcinogenic Agents / pharmacology*
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Cell Line
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Diarylheptanoids / chemistry
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Diarylheptanoids / pharmacology*
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Ear, External / pathology
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Edema / chemically induced
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Edema / prevention & control
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Female
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Herpesvirus 4, Human / drug effects
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Humans
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Japan
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Magnetic Resonance Spectroscopy
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Mice
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Mice, Inbred ICR
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Phenols / chemistry*
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Phenols / pharmacology*
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Plant Bark / chemistry
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Plant Extracts / chemistry
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Plant Extracts / pharmacology
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Plant Stems / chemistry
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Spectrometry, Mass, Electrospray Ionization
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Tetradecanoylphorbol Acetate
Substances
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Anti-Inflammatory Agents, Non-Steroidal
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Anticarcinogenic Agents
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Diarylheptanoids
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Phenols
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Plant Extracts
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acerogenin M
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Tetradecanoylphorbol Acetate