Abstract
The aim of this study was to analyse relationship between changes of the stroma and expression of tenascin-C (TN-C) and laminin in prostate carcinoma. Tenascin-C immunostaining was increased, and laminin decreased in carcinomas compared with peritumoral tissue and benign prostate hyperplasia (P<0.05). Statistical analysis confirmed connection between stromal changes and TN-C expression in prostate carcinoma (P<0.05). Gleason pattern 3 carcinomas showed more pronounced stromal reaction and TN-C expression compared with Gleason pattern 4 carcinomas (P<0.05). The main cells in prostate cancer stroma are myofibroblasts that are also responsible for tenascin production. Degradation of laminin was not connected with myofibroblastic stromal changes.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Actins / metabolism
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Adenocarcinoma / metabolism*
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Adenocarcinoma / pathology
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Adenocarcinoma / surgery
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Aged
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Aged, 80 and over
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Biomarkers, Tumor / metabolism
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Case-Control Studies
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Desmin / metabolism
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Humans
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Immunohistochemistry
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Laminin / metabolism*
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Male
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Middle Aged
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Neoplasm Staging
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Neoplasms, Muscle Tissue / metabolism*
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Neoplasms, Muscle Tissue / pathology
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Neoplasms, Muscle Tissue / surgery
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Prostatectomy
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Prostatic Hyperplasia / metabolism
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Prostatic Hyperplasia / pathology
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Prostatic Hyperplasia / surgery
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Prostatic Neoplasms / metabolism*
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Prostatic Neoplasms / pathology
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Prostatic Neoplasms / surgery
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Stromal Cells / metabolism*
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Stromal Cells / pathology
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Tenascin / metabolism*
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Treatment Outcome
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Vimentin / metabolism
Substances
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Actins
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Biomarkers, Tumor
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Desmin
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Laminin
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Tenascin
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Vimentin