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. 1975 Mar;7(3):289-93.
doi: 10.1128/AAC.7.3.289.

Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice

R J Klein, A E Friedman-Kien

Phosphonoacetic acid-resistant herpes simplex virus infection in hairless mice

R J Klein et al. Antimicrob Agents Chemother. 1975 Mar.

Abstract

Phosphonoacetic acid (PAA)-resistant type 1 herpes simplex virus population was isolated by repeated passage of the virus in the presence of this inhibitor. Hairless mice infected percutaneously with the inhibitor-resistant or the parental inhibitor-susceptible virus were treated intraperitoneally with PAA and 9-beta-d-arabinofuranosyl-adenine by using several different dosage schedules. Whereas 9-beta-d-arabinofuranosyl-adenine was effective both in the PAA-susceptible and PAA-resistant herpes simplex virus-induced skin infection, PAA suppressed only the infection induced by the parental PAA-susceptible virus.

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