Effect of a novel dietary supplement on skin aging in post-menopausal women

Eur J Clin Nutr. 2006 Oct;60(10):1201-6. doi: 10.1038/sj.ejcn.1602438. Epub 2006 May 3.


Objective: The aim of the present study was to quantify the effects on skin in post-menopausal women of a novel dietary supplement (Imedeen Prime Renewal) that contained soy extract, fish protein polysaccharides, extracts from white tea, grape seed and tomato, vitamins C and E as well as zinc and chamomile extract.

Design: The study was a 6-month double blind, placebo controlled, randomized study on healthy post-menopausal females.

Setting: The study was performed at a commercial Contract Research Organisation (TJ Stephens & Associates Inc., TX, USA).

Interventions: Two tablets of Imedeen Prime Renewal or placebo were given twice daily for 6 months.

Subjects: Thirty-eight (active group) and 42 (placebo group) subjects completed the study out of 100.

Results: Clinical grading showed that the active group had a significantly greater improvement (P < 0.05) compared to placebo for the face after 6 months treatment for: forehead, periocular and perioral wrinkles, mottled pigmentation, laxity, sagging, under eye dark circles and overall apperance; skin on the d├ęcolletage after 2, 3 and 6 months treatment and skin on the hand after 3 and 6 months treatment. Photo evaluation showed that the active group had a significantly greater improvement (P < 0.05) on the face after 3 and 6 months for several parameters. Ultrasound measurements showed that the active group had a significantly greater improvement (P < 0.0001) for density measurements after 6 months treatment.

Conclusion: In summary, this novel dietary supplement, Imedeen Prime Renewal, provides improved condition, structure and firmness of the skin in post-menopausal women after 6 months.

Publication types

  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aging / drug effects
  • Aging / physiology*
  • Dietary Supplements
  • Double-Blind Method
  • Female
  • Humans
  • Middle Aged
  • Plant Extracts / pharmacology*
  • Postmenopause
  • Skin / diagnostic imaging
  • Skin / drug effects*
  • Skin / pathology
  • Skin Physiological Phenomena* / drug effects
  • Treatment Outcome
  • Ultrasonography


  • Plant Extracts