The interferon gamma gene polymorphism +874 A/T is associated with severe acute respiratory syndrome

BMC Infect Dis. 2006 May 4;6:82. doi: 10.1186/1471-2334-6-82.


Background: Cytokines play important roles in antiviral action. We examined whether polymorphisms of IFN-gamma,TNF-alpha and IL-10 affect the susceptibility to and outcome of severe acute respiratory syndrome (SARS).

Methods: A case-control study was carried out in 476 Chinese SARS patients and 449 healthy controls. We tested the polymorphisms of IFN-gamma,TNF-alpha and IL-10 for their associations with SARS.

Results: IFN-gamma +874A allele was associated with susceptibility to SARS in a dose-dependent manner (P < 0.001). Individuals with IFN-gamma +874 AA and AT genotype had a 5.19-fold (95% Confidence Interval [CI], 2.78-9.68) and 2.57-fold (95% CI, 1.35-4.88) increased risk of developing SARS respectively. The polymorphisms of IL-10 and TNF-alpha were not associated with SARS susceptibility.

Conclusion: IFN-gamma +874A allele was shown to be a risk factor in SARS susceptibility.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Alleles
  • Female
  • Genetic Predisposition to Disease*
  • Genotype
  • Humans
  • Interferon-gamma / genetics*
  • Interleukin-10 / genetics
  • Male
  • Middle Aged
  • Polymorphism, Single Nucleotide*
  • Risk Factors
  • Severe Acute Respiratory Syndrome / genetics*
  • Tumor Necrosis Factor-alpha / genetics


  • Tumor Necrosis Factor-alpha
  • Interleukin-10
  • Interferon-gamma