Interaction of oxidized low-density lipoprotein and the renin-angiotensin system in coronary artery disease

Curr Hypertens Rep. 2006 May;8(2):139-43. doi: 10.1007/s11906-006-0010-2.


Hyperlipidemia and hypertension are frequently observed in patients with coronary artery disease. It has been proposed that an interaction between low-density lipoprotein, especially its oxidized form (ox-LDL), and renin-angiotensin system (RAS) activation is a major determinant of atherogenesis. Ox-LDL accumulation in the blood vessels enhances the expression and activation of RAS components; on the other hand, activation of RAS stimulates the accumulation of LDL and its oxidation into ox-LDL in the blood vessels. Individually ox-LDL and RAS activation induce oxidative stress and inflammatory cascade, whereas their combination exerts a synergistic effect. This concept of cross-talk between ox-LDL/hyperlipidemia and RAS activation has been proven in laboratory animals. Clinical trials also suggest that blockade of hyperlipidemia and RAS may have a synergistic salutary effect on the outcome of patients with hypertension and/or manifestations of atherosclerosis. This concept needs to be evaluated further in large clinical studies.

Publication types

  • Review

MeSH terms

  • Animals
  • Coronary Artery Disease / metabolism*
  • Humans
  • Hyperlipidemias / metabolism*
  • Hypertension / metabolism*
  • Lipoproteins, LDL / metabolism*
  • Oxidative Stress
  • Renin-Angiotensin System*


  • Lipoproteins, LDL
  • oxidized low density lipoprotein