Stimulation of CRP secretion in HepG2 cells: cooperative effect of dexamethasone and interleukin 6

Agents Actions. 1991 Nov;34(3-4):369-75. doi: 10.1007/BF01988730.

Abstract

This report described the capability of the human. human acute phase reactant, C-reactive protein (CRP). Its secretion is stimulated by interleukin 6 (IL-6) in a dose-dependent fashion and can further be positively modulated by dexamethasone. The way in which this glucocorticoid influences the CRP response depends on its time of application. Incubation of HepG2 cells simultaneously with IL-6 and dexamethasone increases the magnitude of CRP release significantly above that seen with IL-6 alone. After preincubation with dexamethasone, the kinetics of CRP release, induced by IL-6, are increased and approach that observed in the case of alpha 1-acid glycoprotein (alpha 1-AGP) without dexamethasone pretreatment. Conditions for optimal secretion of CRP were determined.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • C-Reactive Protein / biosynthesis
  • C-Reactive Protein / metabolism*
  • Carcinoma, Hepatocellular / metabolism*
  • Dexamethasone / pharmacology*
  • Drug Interactions
  • Humans
  • Interleukin-6 / pharmacology*
  • Kinetics
  • Liver Neoplasms / metabolism*
  • Tumor Cells, Cultured

Substances

  • Interleukin-6
  • Dexamethasone
  • C-Reactive Protein