Multiniche screening reveals the clinically relevant metallo-beta-lactamase VIM-2 in Pseudomonas aeruginosa far from the hospital setting: an ongoing dispersion process?

Appl Environ Microbiol. 2006 May;72(5):3743-5. doi: 10.1128/AEM.72.5.3743-3745.2006.

Abstract

A screening study of the presence of metallo-beta-lactamases (IMP and VIM types and SPM-1) in isolates from different nonhospital sources was conducted, and it revealed the presence of bla(VIM-2), associated with the In58 class 1 integron, in two unrelated Pseudomonas aeruginosa strains from aquatic habitats. The results suggest that the hospital setting was the possible origin of these bla(VIM-2)-carrying strains.

MeSH terms

  • Animals
  • Drug Resistance, Bacterial / genetics
  • Ecosystem
  • Feces / microbiology
  • Gene Transfer, Horizontal*
  • Hospitals*
  • Humans
  • Integrons / genetics
  • Microbial Sensitivity Tests
  • Portugal
  • Pseudomonas aeruginosa / drug effects*
  • Pseudomonas aeruginosa / enzymology
  • Pseudomonas aeruginosa / genetics
  • Pseudomonas aeruginosa / growth & development
  • Rivers / microbiology*
  • Sewage / microbiology*
  • beta-Lactamases / genetics*
  • beta-Lactamases / metabolism
  • beta-Lactams / pharmacology

Substances

  • Sewage
  • beta-Lactams
  • beta-lactamase bla(vim-2)
  • beta-Lactamases