NF-kappaB and cancer: mechanisms and targets

Mol Carcinog. 2006 Jun;45(6):355-61. doi: 10.1002/mc.20217.

Abstract

In addition to being a central coordinator of immune responses, NF-kappaB signaling also plays a critical role in cancer development and progression and it may determine the response to therapy. NF-kappaB activation was shown to provide a critical mechanistic link between inflammation and cancer and is a major factor that controls the ability of both preneoplastic and malignant cells to resist apoptosis-based tumor surveillance mechanisms. NF-kappaB may also be involved in regulation of tumor angiogenesis and invasiveness. Importantly, NF-kappaB and the signaling pathways that mediate its activation have become attractive targets for development of new chemopreventive and chemotherapeutic approaches.

Publication types

  • Review

MeSH terms

  • Cell Transformation, Neoplastic*
  • Colonic Neoplasms / complications
  • Colonic Neoplasms / physiopathology
  • Humans
  • Inflammation / complications
  • Inflammation / physiopathology
  • Liver Neoplasms / chemically induced
  • Liver Neoplasms / complications
  • Liver Neoplasms / physiopathology
  • NF-kappa B / physiology*
  • Signal Transduction
  • Skin Neoplasms / chemically induced
  • Skin Neoplasms / complications
  • Skin Neoplasms / physiopathology

Substances

  • NF-kappa B