No association between chronic musculoskeletal complaints and Val158Met polymorphism in the Catechol-O-methyltransferase gene. The HUNT study

BMC Musculoskelet Disord. 2006 May 4;7:40. doi: 10.1186/1471-2474-7-40.


Background: The Catechol-O-methyltransferase (COMT) gene contains a functional polymorphism, Val158Met, that has been found to influence human pain perception. In one study fibromyalgia was less likely among those with Val/Val genotype.

Methods: In the 1995-97 Nord-Trøndelag Health Study (HUNT), the association between Val/Met polymorphism at the COMT gene and chronic musculoskeletal complaints (MSCs) was evaluated in a random sample of 3017 individuals.

Results: The distribution of the COMT Val158Met genotypes and alleles were similar between controls and the twelve different chronic MSCs groups. Even when the Met/Met and Val/Met genotypes were pooled, the distribution of the Val/Val genotype and other genotypes were similar between controls and the chronic MSCs groups.

Conclusion: In this population-based study, no significant association was found between Val/Met polymorphism at the COMT gene and chronic MSCs.

MeSH terms

  • Adult
  • Aged
  • Alleles
  • Catechol O-Methyltransferase / genetics*
  • Chronic Disease
  • Female
  • Gene Frequency
  • Genotype
  • Humans
  • Male
  • Methionine
  • Middle Aged
  • Musculoskeletal Diseases / genetics*
  • Polymorphism, Genetic*
  • Valine


  • Methionine
  • Catechol O-Methyltransferase
  • Valine