Plant NBS-LRR proteins: adaptable guards

Genome Biol. 2006;7(4):212. doi: 10.1186/gb-2006-7-4-212. Epub 2006 Apr 26.


The majority of disease resistance genes in plants encode nucleotide-binding site leucine-rich repeat (NBS-LRR) proteins. This large family is encoded by hundreds of diverse genes per genome and can be subdivided into the functionally distinct TIR-domain-containing (TNL) and CC-domain-containing (CNL) subfamilies. Their precise role in recognition is unknown; however, they are thought to monitor the status of plant proteins that are targeted by pathogen effectors.

Publication types

  • Review

MeSH terms

  • Amino Acid Sequence
  • Evolution, Molecular
  • Genome, Plant
  • Immunity, Innate / genetics
  • Leucine / analysis
  • Molecular Sequence Data
  • Plant Diseases* / genetics
  • Plant Proteins / chemistry*
  • Plant Proteins / genetics
  • Plant Proteins / physiology
  • Protein Structure, Tertiary
  • Repetitive Sequences, Amino Acid


  • Plant Proteins
  • Leucine