In vivo 13C NMR spectroscopy and metabolic modeling in the brain: a practical perspective

Magn Reson Imaging. 2006 May;24(4):527-39. doi: 10.1016/j.mri.2006.01.003. Epub 2006 Feb 20.


In vivo 13C NMR spectroscopy has the unique capability to measure metabolic fluxes noninvasively in the brain. Quantitative measurements of metabolic fluxes require analysis of the 13C labeling time courses obtained experimentally with a metabolic model. The present work reviews the ingredients necessary for a dynamic metabolic modeling study, with particular emphasis on practical issues.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Brain / metabolism*
  • Carbon Radioisotopes
  • Magnetic Resonance Spectroscopy*
  • Models, Biological
  • Rats


  • Carbon Radioisotopes