The Expanding Cosmos of Nuclear Receptor Coactivators

Cell. 2006 May 5;125(3):411-4. doi: 10.1016/j.cell.2006.04.021.

Abstract

About 200 coactivators play a central role in promoting gene expression mediated by nuclear receptors. This diverse group of proteins are key integrators of signals from steroid hormones and have been implicated in cancer and other diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Active Transport, Cell Nucleus / physiology
  • Animals
  • Cell Nucleus / genetics
  • Cell Nucleus / metabolism*
  • Gene Expression Regulation / physiology
  • Histones / metabolism
  • Humans
  • Receptors, Cytoplasmic and Nuclear / genetics
  • Receptors, Cytoplasmic and Nuclear / metabolism*
  • Regulatory Elements, Transcriptional / physiology
  • Trans-Activators / physiology*
  • Transcription Factors / physiology*
  • Transcriptional Activation / physiology*

Substances

  • Histones
  • Receptors, Cytoplasmic and Nuclear
  • Trans-Activators
  • Transcription Factors