The logic of TGFbeta signaling

FEBS Lett. 2006 May 22;580(12):2811-20. doi: 10.1016/j.febslet.2006.04.033. Epub 2006 Apr 21.


The identification of the TGFbeta cytokine signaling pathway, including membrane receptor serine/threonine kinases and Smad transcription factors as their substrates, has allowed the delineation of a process for conversion of these signals into programs of gene activation and repression that underlie critical cell fate and developmental decisions. The deconstruction of one of these responses - the cell cycle arrest response - into its elemental molecular parts has shed light into the mechanisms used by tumors to evade surveillance and cause metastasis.

Publication types

  • Review

MeSH terms

  • Animals
  • Humans
  • Signal Transduction*
  • Transcription, Genetic
  • Transforming Growth Factor beta / metabolism*


  • Transforming Growth Factor beta