Detection and identification of oligopeptides in Microcystis (cyanobacteria) colonies: toward an understanding of metabolic diversity

Peptides. 2006 Sep;27(9):2090-103. doi: 10.1016/j.peptides.2006.03.014. Epub 2006 May 5.


Cyanobacteria and particularly Microcystis sp. (Chroococcales) are known to produce a multitude of peptide metabolites. Here we report on the mass spectral analysis of cyanobacterial peptides in individual colonies of Microcystis sp. collected in a drinking water reservoir. A total number of more than 90 cyanopeptides could be detected, 61 of which could be identified either as known peptides or new structural variants of known peptide classes. For 18 new peptides flat structures are proposed. New congeners differed from known ones mainly in chlorination (aeruginosins), methylation (microginins), or amino acid sequences (cyanopeptolins). The high number of peptides and especially the new peptides underline the capability of Microcystis strains as producers of a high diversity of potentially bioactive compounds.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Microcystis / chemistry
  • Microcystis / metabolism*
  • Oligopeptides / analysis
  • Oligopeptides / chemistry*
  • Oligopeptides / metabolism
  • Peptides, Cyclic / analysis
  • Peptides, Cyclic / chemistry*
  • Peptides, Cyclic / metabolism
  • Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization


  • Oligopeptides
  • Peptides, Cyclic