14-3-3 Proteins: A Historic Overview

Semin Cancer Biol. 2006 Jun;16(3):162-72. doi: 10.1016/j.semcancer.2006.03.005. Epub 2006 Apr 1.

Abstract

This chapter includes a historic overview of 14-3-3 proteins with an emphasis on the differences between potentially cancer-relevant isoforms on the genomic, protein and functional level. The focus will therefore be on mammalian 14-3-3s although many important developments in the field have involved Drosophila 14-3-3 proteins for example and the cross-fertilisation from parallel studies on plant 14-3-3 should not be underestimated. In the major part of this review I will attempt to focus on some novel data and aspects of 14-3-3 structure and function, in particular regulation of 14-3-3 isoforms by oncogene-related protein kinase phosphorylation and aspects of 14-3-3 research with which newcomers to the field may be less familiar.

Publication types

  • Historical Article
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • 14-3-3 Proteins / history
  • 14-3-3 Proteins / isolation & purification
  • 14-3-3 Proteins / metabolism*
  • Amino Acid Sequence
  • Animals
  • Dimerization
  • Drosophila / metabolism
  • History, 20th Century
  • Molecular Sequence Data
  • Phosphorylation
  • Protein Binding
  • Protein Isoforms / chemistry*
  • Protein Isoforms / metabolism*
  • Protein Kinases / metabolism
  • Protein Structure, Tertiary
  • Signal Transduction
  • Terminology as Topic

Substances

  • 14-3-3 Proteins
  • Protein Isoforms
  • Protein Kinases