More than just the postal service: novel roles for IFT proteins in signal transduction

Dev Cell. 2006 May;10(5):541-2. doi: 10.1016/j.devcel.2006.04.010.


Disruption of intraflagellar transport (IFT) results in loss of flagella and cilia as well as their signaling activity, making it difficult to assess possible roles of IFT in signal transduction. In a recent issue of Cell, Wang et al. (2006) used a temperature-sensitive IFT mutant to separate flagella assembly from signaling activity, and they show that IFT has a direct role in forming signaling complexes in the flagella.

MeSH terms

  • Animals
  • Biological Transport
  • Chlamydomonas reinhardtii / cytology
  • Chlamydomonas reinhardtii / metabolism
  • Cilia / chemistry
  • Cilia / metabolism
  • Flagella / chemistry*
  • Flagella / metabolism*
  • Signal Transduction*