Randomized clinical study of Hydrofiber dressing with silver or silver sulfadiazine in the management of partial-thickness burns

J Burn Care Res. May-Jun 2006;27(3):298-309. doi: 10.1097/01.BCR.0000216741.21433.66.

Abstract

This prospective, randomized study compared protocols of care using either AQUACEL Ag Hydrofiber (ConvaTec, a Bristol-Myers Squibb company, Skillman, NJ) dressing with silver (n = 42) or silver sulfadiazine (n = 42) for up to 21 days in the management of partial-thickness burns covering 5% to 40% body surface area (BSA). AQUACEL Ag dressing was associated with less pain and anxiety during dressing changes, less burning and stinging during wear, fewer dressing changes, less nursing time, and fewer procedural medications. Silver sulfadiazine was associated with greater flexibility and ease of movement. Adverse events, including infection, were comparable between treatment groups. The AQUACEL Ag dressing protocol tended to have lower total treatment costs (Dollars 1040 vs. Dollars 1180) and a greater rate of re-epithelialization (73.8% vs 60.0%), resulting in cost-effectiveness per burn healed of Dollars 1,409.06 for AQUACEL Ag dressing and Dollars 1,967.95 for silver sulfadiazine. A protocol of care with AQUACEL(R) Ag provided clinical and economic benefits compared with silver sulfadiazine in patients with partial-thickness burns.

Publication types

  • Multicenter Study
  • Randomized Controlled Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged, 80 and over
  • Anti-Infective Agents, Local / adverse effects
  • Anti-Infective Agents, Local / economics
  • Anti-Infective Agents, Local / therapeutic use*
  • Burns / drug therapy*
  • Carboxymethylcellulose Sodium / adverse effects
  • Carboxymethylcellulose Sodium / economics
  • Carboxymethylcellulose Sodium / therapeutic use*
  • Child, Preschool
  • Cicatrix / prevention & control
  • Cost-Benefit Analysis
  • Epithelium / growth & development
  • Health Care Costs / statistics & numerical data
  • Humans
  • Infant
  • Male
  • Occlusive Dressings / adverse effects
  • Occlusive Dressings / economics*
  • Outcome Assessment, Health Care
  • Pain Measurement
  • Pediatrics
  • Prospective Studies
  • Silver / adverse effects
  • Silver / economics
  • Silver / therapeutic use*
  • Silver Sulfadiazine / adverse effects
  • Silver Sulfadiazine / economics
  • Silver Sulfadiazine / therapeutic use*

Substances

  • Anti-Infective Agents, Local
  • Silver
  • Carboxymethylcellulose Sodium
  • Silver Sulfadiazine