Signal transduction and the fate of the R7 photoreceptor in Drosophila

Trends Genet. Nov-Dec 1991;7(11-12):372-7. doi: 10.1016/0168-9525(91)90258-r.

Abstract

The sevenless protein tyrosine kinase receptor plays a central role in the pathway of cell fate induction that determines the development of the R7 photoreceptor in the Drosophila eye. In the last year we have learned much about the probable ligand for sevenless and have begun to dissect the signal transduction pathway that relays the information from the sevenless kinase. Studies of the mechanisms governing the specificity of signal transmission and reception suggest that the sevenless signal directs a bipotential cell towards a neuronal rather than a cone cell fate.

Publication types

  • Review

MeSH terms

  • Animals
  • Drosophila Proteins*
  • Drosophila melanogaster / physiology*
  • Eye / growth & development
  • Eye Proteins / genetics
  • Eye Proteins / physiology*
  • Gene Expression Regulation
  • Genes
  • Membrane Glycoproteins / genetics
  • Membrane Glycoproteins / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Models, Genetic
  • Photoreceptor Cells / metabolism*
  • Protein-Tyrosine Kinases / genetics
  • Protein-Tyrosine Kinases / physiology*
  • Receptor Protein-Tyrosine Kinases*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Receptors, Peptide*
  • Recombinant Fusion Proteins / biosynthesis
  • Signal Transduction*
  • Suppression, Genetic

Substances

  • Drosophila Proteins
  • Eye Proteins
  • Membrane Glycoproteins
  • Membrane Proteins
  • Receptors, Cell Surface
  • Receptors, Peptide
  • Recombinant Fusion Proteins
  • boss protein, Drosophila
  • Protein-Tyrosine Kinases
  • Receptor Protein-Tyrosine Kinases
  • sev protein, Drosophila