Choosing a cell fate: a view from the Notch locus

Trends Genet. Nov-Dec 1991;7(11-12):403-8. doi: 10.1016/0168-9525(91)90264-q.


During the development of Drosophila melanogaster, individual cells must make choices between a restricted set of possible fates in order to give rise to spatial patterns composed of different types of differentiated cells. The Notch locus appears to play a central and general role in the regulative events that control the local architecture of the final cellular pattern in several tissues, among them being the central and peripheral nervous systems.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation
  • Drosophila Proteins
  • Drosophila melanogaster / embryology*
  • Drosophila melanogaster / genetics
  • Ectoderm
  • Embryonic Development
  • Embryonic and Fetal Development
  • Epistasis, Genetic
  • Feedback
  • Gene Expression Regulation
  • Genes
  • Insect Hormones / genetics
  • Insect Hormones / physiology*
  • Membrane Proteins / genetics
  • Membrane Proteins / physiology*
  • Mosaicism
  • Nervous System / embryology
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology
  • Receptors, Notch


  • Drosophila Proteins
  • Insect Hormones
  • Membrane Proteins
  • N protein, Drosophila
  • Receptors, Cell Surface
  • Receptors, Notch