Is PDGF really important? Testing the hypotheses

Trends Genet. Nov-Dec 1991;7(11-12):413-8.

Abstract

Platelet-derived growth factor (PDGF) has been proposed to be one of the growth factors that drive proliferation during normal development and in various pathological conditions. Support for these hypotheses has been largely circumstantial. We discuss the pros and cons of the different experimental approaches that have been taken to test these hypotheses, and evaluate the information to be gained by characterizing the consequences of deletion of one of the PDGF receptor genes in the Patch mutant mouse.

Publication types

  • Review

MeSH terms

  • Animals
  • Cell Division / physiology
  • Connective Tissue / metabolism
  • Connective Tissue Cells
  • Embryonic and Fetal Development / genetics
  • Embryonic and Fetal Development / physiology
  • Gene Expression Regulation
  • Genes, Lethal
  • Heterozygote
  • Humans
  • Mice
  • Mice, Mutant Strains / embryology
  • Mice, Mutant Strains / genetics
  • Models, Biological
  • Platelet-Derived Growth Factor / genetics
  • Platelet-Derived Growth Factor / physiology*
  • Receptors, Cell Surface / genetics
  • Receptors, Cell Surface / physiology*
  • Receptors, Platelet-Derived Growth Factor
  • Wound Healing

Substances

  • Platelet-Derived Growth Factor
  • Receptors, Cell Surface
  • Receptors, Platelet-Derived Growth Factor