The maintenance and masking of chromosome termini

Curr Opin Cell Biol. 2006 Jun;18(3):247-53. doi: 10.1016/ Epub 2006 May 8.


Telomeres, the natural termini of eukaryotic chromosomes, have been the subject of intense interest during the last decade because of the roles that these chromosome termini perform in both cancer and aging. As we become more cognizant of the consequences of telomere dysfunction on several aspects of human health, significant attention is focused on understanding at a molecular level how the many telomere-associated factors perform their activities.

Publication types

  • Review

MeSH terms

  • Cell Cycle Proteins / antagonists & inhibitors
  • DNA Damage
  • Genes, cdc
  • Humans
  • Models, Genetic
  • Telomerase / metabolism
  • Telomere*
  • Telomere-Binding Proteins / metabolism


  • Cell Cycle Proteins
  • Telomere-Binding Proteins
  • Telomerase