The second messenger cascade in olfactory receptor neurons

Curr Opin Neurobiol. 1991 Aug;1(2):204-8. doi: 10.1016/0959-4388(91)90079-m.


The molecular cloning of components involved in the cAMP second messenger cascade has allowed their biochemical characterization and revealed properties that are important for their role in sensory transduction. Recent evidence suggests inositol 1,4,5-trisphosphate functions as an additional second messenger in olfactory signalling. The interaction of these two pathways may contribute to the sensitivity of the olfactory system.

Publication types

  • Review

MeSH terms

  • Animals
  • Cyclic AMP / physiology
  • Humans
  • Neurons / physiology*
  • Odorants
  • Second Messenger Systems*
  • Sensory Receptor Cells / physiology*
  • Signal Transduction
  • Smell / physiology*


  • Cyclic AMP