SIRT1 and Endocrine Signaling

Trends Endocrinol Metab. 2006 Jul;17(5):186-91. doi: 10.1016/j.tem.2006.04.002. Epub 2006 May 8.

Abstract

Sirtuins (Sir2-related enzymes) are a recently discovered class of NAD(+)-dependent protein deacetylases that regulate gene expression in a variety of organisms by deacetylation of modified lysine residues on histones, transcription factors and other proteins. Conservation of sirtuin regulation of the insulin-insulin-like growth factor I signaling pathway has been observed for Caenorhabditis elegans and mammals, indicating an ancient role for sirtuins in the modulation of organism adaptations to nutritional intake. The human sirtuin SIRT1 regulates a number of transcription factors that modulate endocrine signaling, including peroxisome proliferator-activated receptor gamma, peroxisome proliferator-activated receptor gamma coactivator 1alpha, forkhead-box transcription factors and p53.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adipocytes / metabolism
  • Animals
  • Apoptosis
  • Cellular Senescence
  • Endocrine Glands / physiology*
  • Evolution, Molecular
  • Forkhead Transcription Factors / metabolism
  • Glucose / metabolism
  • Growth Substances / metabolism
  • Humans
  • Insulin / metabolism
  • Insulin Secretion
  • Insulin-Like Growth Factor I / metabolism
  • Liver / metabolism
  • PPAR gamma / metabolism
  • Pancreas / metabolism
  • Signal Transduction*
  • Sirtuin 1
  • Sirtuins / physiology*
  • Synteny

Substances

  • Forkhead Transcription Factors
  • Growth Substances
  • Insulin
  • PPAR gamma
  • Insulin-Like Growth Factor I
  • SIRT1 protein, human
  • Sirtuin 1
  • Sirtuins
  • Glucose