[Pregnancy complications as a risk factor for metabolic and cardiovascular disease in later life]

Ned Tijdschr Geneeskd. 2006 Apr 22;150(16):898-902.
[Article in Dutch]


In recent years several large epidemiological studies have been published that demonstrate that women who experience gestational diabetes, pregnancy-induced hypertension or pre-eclampsia have an increased risk of developing type-2 diabetes mellitus and cardiovascular disease. 15-50% of women who experience gestational diabetes develop type-2 diabetes mellitus; the risk is particularly high in those who require insulin therapy during pregnancy. - Chronic hypertension frequently develops years after a pregnancy complicated by pregnancy-induced hypertension, especially in women who have had pregnancy-induced hypertension in multiple pregnancies. Women who experience pre-eclampsia in the first 36 weeks of pregnancy or in multiple pregnancies have an increased risk of cardiovascular morbidity and mortality in later life. Therefore gestational diabetes, pregnancy-induced hypertension and pre-eclampsia provide an opportunity to identify individuals with an increased risk of type-2 diabetes mellitus and cardiovascular disease at an early age. This may create new perspectives on prevention.

Publication types

  • English Abstract
  • Review

MeSH terms

  • Adult
  • Cardiovascular Diseases / epidemiology*
  • Diabetes Mellitus, Type 2 / epidemiology*
  • Diabetes, Gestational / physiopathology
  • Female
  • Humans
  • Hypertension, Pregnancy-Induced / physiopathology
  • Pre-Eclampsia / physiopathology
  • Pregnancy
  • Pregnancy Complications*
  • Risk Factors