New insights into the molecular biology and targeted therapy of cutaneous T-cell lymphomas

J Dtsch Dermatol Ges. 2006 May;4(5):395-406. doi: 10.1111/j.1610-0387.2006.05982.x.


Cutaneous T-cell lymphoma is an extra-nodal non-Hodgkin lymphoma of mature T cells. These tumor cells home to and persist in the skin,producing a broad spectrum of clinical entities. Recent results of basic research on tumor biology and tumor immunology as well as molecular genetics of cutaneous T-cell lymphoma have fostered the development of new therapeutic approaches. Several clinical trials testing these targeted therapies have shown encouraging results. This article provides an overview of recent research developments and therapeutic strategies for cutaneous T-cell lymphoma.

Publication types

  • Review

MeSH terms

  • Animals
  • Antineoplastic Agents / administration & dosage*
  • Drug Delivery Systems / methods
  • Drug Delivery Systems / trends*
  • Gene Targeting / methods
  • Gene Targeting / trends
  • Genetic Therapy / methods
  • Genetic Therapy / trends*
  • Humans
  • Lymphoma, T-Cell / drug therapy*
  • Lymphoma, T-Cell / physiopathology*
  • Molecular Biology / trends
  • Skin Neoplasms / drug therapy*
  • Skin Neoplasms / physiopathology*


  • Antineoplastic Agents