Chromosome territories--a functional nuclear landscape

Curr Opin Cell Biol. 2006 Jun;18(3):307-16. doi: 10.1016/ Epub 2006 May 9.


Understanding nuclear architecture is indispensable for understanding the cell-type-dependent orchestration of active and silent genes and other nuclear functions, such as RNA splicing, DNA replication and repair. Yet, while it is now generally agreed that chromosomes in the cell nucleus are organized as chromosome territories, present models of chromosome territory architecture differ widely with respect to the possible functional implications of dynamic changes of this architecture during the cell cycle and terminal cell differentiation.

Publication types

  • Review

MeSH terms

  • Animals
  • Chromatin Assembly and Disassembly
  • Chromosome Structures / genetics*
  • Humans
  • Models, Genetic*
  • Models, Molecular
  • Molecular Conformation