Long-term longitudinal study on the relationship between alternating shift work and the onset of diabetes mellitus in male Japanese workers

J Occup Environ Med. 2006 May;48(5):455-61. doi: 10.1097/01.jom.0000214355.69182.fa.


Objective: This study investigated the effect of alternating shift work (ASW) on the onset of diabetes mellitus in Japanese workers compared with onset in day-shift work (DSW).

Methods: A longitudinal study was carried out on a DSW group (n = 3203) and ASW group (n = 2426) of a steel company who received their annual health checkups over a 10-year period between 1991 and 2001. The association between job schedule type and onset of diabetes mellitus (glycated hemoglobin A1c > or =6.0% or medication) was investigated by multivariate pooled logistic regression analyses.

Results: The odds ratio (95% confidence interval) for the development of diabetes mellitus in the ASW group compared with the DSW group was 1.35 (1.05-1.75).

Conclusions: Our study revealed that the ASW is an independent risk factor for the onset of diabetes mellitus.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Diabetes Mellitus / epidemiology*
  • Humans
  • Japan / epidemiology
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Odds Ratio
  • Risk Factors
  • Work Schedule Tolerance*