Monitoring chemotherapy and radiotherapy of solid tumors

Eur J Nucl Med Mol Imaging. 2006 Jul;33 Suppl 1:27-37. doi: 10.1007/s00259-006-0133-3.

Abstract

PET imaging with the glucose analog fluorodeoxyglucose (FDG-PET) has been evaluated in numerous studies to monitor tumor response in patients undergoing chemo- and radiotherapy. The clinical value of FDG-PET for differentiation of residual or recurrent viable tumor and therapy-induced fibrosis or scar tissue has been documented for various solid tumors. Furthermore, there are now several reports suggesting that quantitative assessment of therapy-induced changes in tumor FDG uptake may allow prediction of tumor response and patient outcome very early in the course of therapy. In nonresponding patients, treatment may be adjusted according to the individual chemo- and radiosensitivity of the tumor tissue. Since the number of alternative treatments for solid tumors (e.g., second-line chemotherapy agents, protein kinase, or angiogenesis inhibitors) is continuously increasing, early prediction of tumor response to chemotherapy and radiotherapy by FDG-PET has enormous potential to "personalize" treatment and to reduce the side-effects and costs of ineffective therapy.

Publication types

  • Review

MeSH terms

  • Esophageal Neoplasms / diagnostic imaging
  • Esophageal Neoplasms / drug therapy
  • Esophageal Neoplasms / radiotherapy
  • Female
  • Fluorodeoxyglucose F18*
  • Head and Neck Neoplasms / diagnostic imaging
  • Head and Neck Neoplasms / drug therapy
  • Head and Neck Neoplasms / radiotherapy
  • Humans
  • Lung Neoplasms / diagnostic imaging
  • Lung Neoplasms / drug therapy
  • Lung Neoplasms / radiotherapy
  • Monitoring, Physiologic / methods
  • Neoplasms / diagnostic imaging
  • Neoplasms / drug therapy*
  • Neoplasms / radiotherapy*
  • Radionuclide Imaging
  • Radiopharmaceuticals
  • Sarcoma / diagnostic imaging
  • Sarcoma / drug therapy
  • Sarcoma / radiotherapy
  • Uterine Cervical Neoplasms / diagnostic imaging
  • Uterine Cervical Neoplasms / drug therapy
  • Uterine Cervical Neoplasms / radiotherapy

Substances

  • Radiopharmaceuticals
  • Fluorodeoxyglucose F18