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. 2006 Feb;4(1):1-9.
doi: 10.1016/S1672-0229(06)60010-7.

Sequence Similarity and Functional Relationship Among Eukaryotic ZIP and CDF Transporters

Free PMC article

Sequence Similarity and Functional Relationship Among Eukaryotic ZIP and CDF Transporters

Taiho Kambe et al. Genomics Proteomics Bioinformatics. .
Free PMC article


ZIP (ZRT/IRT-like Protein) and CDF (Cation Diffusion Facilitator) are two large metal transporter families mainly transporting zinc into and out of the cytosol. Several ZIP and CDF transporters have been characterized in mammals and various model organisms, such as yeast, nematode, fruit fly, and zebrafish, and many candidate genes have been identified by genome projects. Unexpected functions of ZIP and CDF transporters have been recently reported in some model organisms, leading to major advances in our understanding of the functions of mammalian counterparts. Here, we review the recent information on the sequence similarity and functional relationship among eukaryotic ZIP and CDF transporters obtained from the representative model organisms.


Fig. 1
Fig. 1
A dendrogram showing the sequence similarity and the class of subfamily of human ZIP and CDF (ZnT) family members. The dendrogram was generated by using the GENETYX-MAC software, and the class of subfamily follows the assignment by Gaither and Eide . The class of members of the LIV1/LZT subfamily lacking the initial histidine in the HEXPHEXGD motif is indicated as LIV1/LZT* subfamily. [This figure has been modified from Kambe et al. with permission from Birkhäuser Publishing, Basel, Switzerland.]

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    1. Vallee B.L., Falchuk K.H. The biochemical basis of zinc physiology. Physiol. Rev. 1993;73:79–118. - PubMed
    1. Berg J.M., Shi Y. The galvanization of biology: a growing appreciation for the roles of zinc. Science. 1996;271:1081–1085. - PubMed
    1. Krishna S.S. Structural classification of zinc fingers: survey and summary. Nucleic Acids Res. 2003;31:532–550. - PMC - PubMed
    1. Kambe T. Overview of mammalian zinc transporters. Cell. Mol. Life Sci. 2004;61:49–68. - PubMed
    1. Gaither L.A., Eide D.J. Eukaryotic zinc transporters and their regulation. Biometals. 2001;14:251–270. - PubMed

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