The where's and when's of kinase anchoring

Trends Biochem Sci. 2006 Jun;31(6):316-23. doi: 10.1016/j.tibs.2006.04.009. Epub 2006 May 11.


Kinase anchoring has gained acceptance as a means to synchronize spatial and temporal aspects of cell signaling. A-kinase anchoring proteins (AKAPs) are a diverse group of functionally related proteins that target protein kinase A and other enzymes to coordinate a range of signaling events. Recent advances in this field have shown that incorporating phosphodiesterases into AKAP signaling complexes exerts local control of cAMP metabolism, that phosphorylation of some AKAPs potentiates downstream signaling events, that anchoring of distinct enzyme combinations functions as a mechanism to expand the repertoire of cellular events controlled by a single AKAP, and that fluorescent biosensors can be used to visualize dynamic aspects of localized cAMP signaling.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Adaptor Proteins, Signal Transducing / metabolism*
  • Animals
  • Cyclic AMP / metabolism*
  • Cyclic AMP-Dependent Protein Kinases / metabolism*
  • Humans
  • Protein Processing, Post-Translational / physiology*
  • Signal Transduction / physiology*


  • Adaptor Proteins, Signal Transducing
  • Cyclic AMP
  • Cyclic AMP-Dependent Protein Kinases