Retropharyngeal lymph node metastasis from olfactory neuroblastoma: A report of two cases

Eur Arch Otorhinolaryngol. 2006 Aug;263(8):778-82. doi: 10.1007/s00405-006-0048-4. Epub 2006 May 12.


Olfactory neuroblastoma is a rare, malignant neoplasm arising from the olfactory epithelium. It has an aggressive biological behavior that is characterized by local recurrence, atypical distant metastasis, and poor long-term prognosis. The incidence of cervical lymph node metastasis in olfactory neuroblastoma is variable, and treatment modalities are controversial. Moreover, few reports have been published concerning retropharyngeal lymph node metastasis from olfactory neuroblastoma. We present two cases of olfactory neuroblastoma with retropharyngeal lymph node metastasis. In addition, we provided a review of the current literature regarding olfactory neuroblastoma and retropharyngeal lymph node metastasis from olfactory neuroblastoma.

Publication types

  • Case Reports
  • Review

MeSH terms

  • Adult
  • Esthesioneuroblastoma, Olfactory / secondary*
  • Esthesioneuroblastoma, Olfactory / surgery
  • Esthesioneuroblastoma, Olfactory / therapy
  • Humans
  • Immunohistochemistry
  • Lymph Nodes / diagnostic imaging
  • Lymph Nodes / pathology*
  • Lymphatic Metastasis
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Nasal Cavity / pathology*
  • Nose Neoplasms / pathology*
  • Nose Neoplasms / surgery
  • Nose Neoplasms / therapy
  • Pharynx
  • Radiotherapy, Adjuvant
  • Tomography, X-Ray Computed