Studies of Ca2+ ATPase (SERCA) inhibition

J Bioenerg Biomembr. 2005 Dec;37(6):365-8. doi: 10.1007/s10863-005-9472-1.

Abstract

The Ca(2+) transport ATPase of intracellular membranes (SERCA) can be inhibited by a series of chemical compounds such as Thapsigargin (TG), 2,5-di(tert-butyl)hydroquinone (DBHQ) and 1,3-dibromo-2,4,6-tris (methyl-isothio-uronium) benzene (Br(2)-TITU). These compounds have specific binding sites in the ATPase protein, and different mechanisms of inhibition. On the other hand, SERCA gene silencing offers a convenient and specific method for suppression of SERCA activity in cells. The physiological and pharmacological implications of SERCA inhibition are discussed.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Binding Sites
  • Calcium-Transporting ATPases / antagonists & inhibitors*
  • Enzyme Inhibitors / pharmacology
  • Gene Silencing / drug effects
  • RNA, Small Interfering / pharmacology

Substances

  • Enzyme Inhibitors
  • RNA, Small Interfering
  • Calcium-Transporting ATPases