The T-box transcription factor T-bet in immunity and autoimmunity

Cell Mol Immunol. 2006 Apr;3(2):87-95.


The T-box transcription factor T-bet (Tbx21) has emerged as a key regulator of type 1-like immunity, playing critical roles in the establishment and/or maintenance of effector cell fates in T and B lymphocytes, as well as dendritic cells and natural killer cells. Several autoimmune diseases, especially those classically considered related to T helper 1 (Th1) immunity, appear to require T-bet, at least as judged in mouse models. This review summarizes a current understanding of T-bet's role in immunity, as well as its importance in autoimmunity, with implications for therapeutic intervention.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / drug therapy
  • Autoimmune Diseases / immunology*
  • B-Lymphocytes / immunology
  • Drug Delivery Systems
  • Humans
  • Immunity*
  • T-Box Domain Proteins
  • T-Lymphocytes / immunology
  • Transcription Factors / immunology*


  • T-Box Domain Proteins
  • T-box transcription factor TBX21
  • Transcription Factors