Potent hFPRL1 (ALXR) agonists as potential anti-inflammatory agents

Bioorg Med Chem Lett. 2006 Jul 15;16(14):3713-8. doi: 10.1016/j.bmcl.2006.04.068. Epub 2006 May 11.


We report the discovery of potent agonists for the human formyl-peptide-like 1 receptor (hFPRL1). These compounds did not act at a closely related receptor denoted human formyl peptide receptor (hFPR) up to 10 microM concentration. Recent studies have indicated that agonizing this receptor may promote resolution of inflammation. In an exploratory study, a novel hFPRL1 agonist showed efficacy in a mouse ear inflammation model following oral administration.

MeSH terms

  • Administration, Oral
  • Animals
  • Anti-Inflammatory Agents / chemistry*
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Disease Models, Animal
  • Dose-Response Relationship, Drug
  • Humans
  • Inflammation / drug therapy*
  • Mice
  • Molecular Structure
  • Receptors, Formyl Peptide / agonists*
  • Receptors, Lipoxin / agonists*


  • Anti-Inflammatory Agents
  • FPR2 protein, human
  • Receptors, Formyl Peptide
  • Receptors, Lipoxin