Mitochondrial DNA transcription and diseases: past, present and future

Biochim Biophys Acta. Sep-Oct 2006;1757(9-10):1179-89. doi: 10.1016/j.bbabio.2006.03.023. Epub 2006 Apr 7.

Abstract

The transcription of mitochondrial DNA has been studied for 30 years. However, many of the earlier observations are still unsolved. In this review we will recall the basis of mitochondrial DNA transcription, established more than twenty years ago, will include some of the recent progress in the understanding of this process and will suggest hypotheses for some of the unexplained topics. Moreover, we will show some examples of mitochondrial pathology due to altered transcription and RNA metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Base Sequence
  • DNA, Mitochondrial / genetics*
  • Humans
  • Mitochondrial Diseases / genetics*
  • Molecular Sequence Data
  • Nucleic Acid Conformation
  • RNA / chemistry
  • RNA / genetics
  • RNA Processing, Post-Transcriptional / genetics
  • RNA, Mitochondrial
  • Transcription, Genetic*

Substances

  • DNA, Mitochondrial
  • RNA, Mitochondrial
  • RNA