Host defence peptides from invertebrates--emerging antimicrobial strategies

Immunobiology. 2006;211(4):315-22. doi: 10.1016/j.imbio.2005.10.017. Epub 2006 Apr 17.


Cationic antimicrobial (host defence) peptides are found as potent components of the innate immune system of all invertebrates in which they have been investigated. They vary substantially in their amino acid sequences, secondary structures, inducibility, potency and antimicrobial activity spectra. This enormous diversity is providing templates for the design and development of both antibiotic peptides and peptides that selectively modulate innate immunity to increase protection against infections and sepsis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Antimicrobial Cationic Peptides / chemistry*
  • Antimicrobial Cationic Peptides / physiology*
  • Invertebrates / immunology*
  • Molecular Sequence Data


  • Antimicrobial Cationic Peptides