MICA, MICB, and MHC beta block matching in bone marrow transplantation: relevance to transplantation outcome

Hum Immunol. 2006 Mar;67(3):238-46. doi: 10.1016/j.humimm.2006.02.012. Epub 2006 Mar 29.

Abstract

Genetic testing of the MHC is required for selection of donors for bone marrow transplantation. The outcome of related bone marrow transplantation is usually superior to that of unrelated bone marrow transplantation. This may be the result of inaccurate or incomplete genetic testing employed for selection of donor for transplantation. Based on MHC haplotype matching, MHC block matching has been developed for selection of potential unrelated donor. Block matching has been shown previously to improve outcome when added to the conventional method of human leukocyte antigen (HLA) typing for selection of donors. In this study, we have retrospectively analyzed 44 donor recipient pairs from the Australian Bone Marrow Donor Registry Repository with respect to matching of HLA-B and HLA-Cw by sequence-based typing and MICA and MICB by polymerase chain reaction-sequence specific primer and MHC beta block matching and correlated these results with survival. Beta block matching was correlated with MIC matching (p < 0.005) and with HLA-B and HLA-Cw matching. Patients who were HLA-B and -Cw matched had significantly improved survival when they were additionally matched for MHC beta block (p(c) = 0.04) or MIC (p(c) = 0.05).

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Bone Marrow Transplantation / immunology*
  • Bone Marrow Transplantation / mortality
  • Child
  • Donor Selection
  • Female
  • HLA-B Antigens / immunology*
  • HLA-C Antigens / immunology*
  • Histocompatibility Antigens Class I / immunology*
  • Histocompatibility Testing
  • Humans
  • Major Histocompatibility Complex / immunology*
  • Male
  • Middle Aged
  • Retrospective Studies
  • Survival Rate
  • Transplantation Tolerance

Substances

  • HLA-B Antigens
  • HLA-C Antigens
  • Histocompatibility Antigens Class I
  • MHC class I-related chain A
  • MICB antigen