Plasma-binding globulins and acute stress response

Horm Metab Res. 2006 Apr;38(4):260-8. doi: 10.1055/s-2006-925347.


Within studies of acute stress physiology an increase in glucocorticoid secretion is thought to be the primary mediator of tissue response to stress. Corticosteroid-binding globulin may regulate tissue availability of steroids, but has not been considered a dynamic component of the acute stress response. Here, we examined CBG level over the common 60-minute time frame in an acute capture and handling protocol to investigate whether CBG capacity is dynamic or static over short stressors. Using a comparative approach, we measured CBG response to capture and handling stress in nine species of birds, representing five orders and nine families. CBG capacity significantly declined within 30 - 60 minutes of capture in five of the nine species examined. This decline may serve to significantly increase the level of corticosterone reaching tissues during acute stress.

Publication types

  • Comparative Study
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Acute-Phase Reaction / blood*
  • Animals
  • Birds / blood*
  • Birds / physiology
  • Body Constitution
  • Charadriiformes / blood
  • Corticosterone / blood
  • Falconiformes / blood
  • Female
  • Finches / blood
  • Galliformes / blood
  • Handling, Psychological
  • Male
  • Passeriformes / blood
  • Phylogeny
  • Stress, Physiological
  • Time Factors
  • Transcortin / metabolism*


  • Transcortin
  • Corticosterone