Metoclopramide for migraine-associated hiccup

Int J Clin Pract. 2006 May;60(5):604-5. doi: 10.1111/j.1368-5031.2006.00844.x.


Persistent hiccup can be a distressing disorder. I present a case of migraine-attack-associated sustained hiccup. Metoclopramide can swiftly control both hiccup and migraine headache. Vasopressin release probably underlies migraine-aborting action of metoclopramide while restoration of oesophageal smooth muscle function involves competitive dopaminergic antagonism and a prominent cholinergic agonist activity. Episodic prolonged hiccup associated with nausea is an unusual presenting feature of migraine.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Antiemetics / therapeutic use*
  • Dopamine Antagonists / therapeutic use
  • Hiccup / drug therapy*
  • Hiccup / etiology
  • Humans
  • Male
  • Metoclopramide / therapeutic use*
  • Migraine Disorders / complications
  • Migraine Disorders / drug therapy*


  • Antiemetics
  • Dopamine Antagonists
  • Metoclopramide