AFM study of the effect of metronidazole on surface structures of sulfate-reducing bacteria

Anaerobe. 2006 Apr;12(2):106-9. doi: 10.1016/j.anaerobe.2005.12.002. Epub 2006 Feb 3.


The effect of metronidazole (ME) on sulfate-reducing bacteria (SRB) was studied by atomic force microscopy (AFM) in this paper. Topography images of SRB cell show that after exposure to ME individual cell shape is sharply modified. Topography and phase images of SRB cell wall show that after exposure to ME not only the roughness of the cell wall increases but also the physical performance of SRB surface is changed to be uniform. AFM frictional loops show that after exposure to ME, SRB surface friction is increased remarkably.

Publication types

  • Comparative Study

MeSH terms

  • Anti-Infective Agents / pharmacology*
  • Cell Wall / drug effects
  • Cell Wall / ultrastructure
  • Desulfovibrio vulgaris / drug effects*
  • Desulfovibrio vulgaris / ultrastructure
  • Friction
  • Metronidazole / pharmacology*
  • Microscopy, Atomic Force / methods


  • Anti-Infective Agents
  • Metronidazole