Breaking the (un)sound barrier: filaggrin is a major gene for atopic dermatitis

J Invest Dermatol. 2006 Jun;126(6):1200-2. doi: 10.1038/sj.jid.5700365.


We have recently shown that loss-of-function mutations in the filaggrin gene, carried by about 10% of people of European ethnicity, cause ichthyosis vulgaris and are strong predisposing factors for atopic dermatitis and asthma secondary to atopic dermatitis. These results demonstrate a prominent role for the epidermal barrier in atopic disease and have important implications for the study of complex traits.

MeSH terms

  • Child
  • Dermatitis, Atopic / genetics*
  • Dermatitis, Atopic / metabolism
  • Genes / genetics
  • Genetic Predisposition to Disease*
  • Humans
  • Intermediate Filament Proteins / analysis
  • Intermediate Filament Proteins / deficiency*
  • Intermediate Filament Proteins / genetics*
  • Mutation
  • Skin / chemistry
  • Skin / metabolism*


  • Intermediate Filament Proteins
  • filaggrin