PSORS1: linking genetics and immunology

J Invest Dermatol. 2006 Jun;126(6):1205-6. doi: 10.1038/sj.jid.5700357.


Previous studies have localized the psoriasis susceptibility 1 (PSORS1) locus to the proximal major histocompatibility complex class I region, but approximately a dozen genes in the candidate region have thus far been genetically inseparable. According to a team of researchers in the United States and Germany, the primary genetic association has now been worked out, implicating HLA-Cw6 "after all." The results integrate genetics and immunology, further reinforcing our emerging understanding of psoriasis.

MeSH terms

  • Genetic Linkage
  • HLA-C Antigens / genetics*
  • Humans
  • Immunity / genetics
  • Proteins / genetics
  • Psoriasis / genetics*
  • Psoriasis / immunology*


  • HLA-C Antigens
  • HLA-C*06 antigen
  • PSORS1C1 protein, human
  • Proteins