Genomic instability and tumor stem cells

J Invest Dermatol. 2006 Jun;126(6):1214-6. doi: 10.1038/sj.jid.5700240.


Wang et al. point to the existance of a common progenitor tumor stem cell that gives rise to genomically unstable progeny in malignant melanoma. Although it is not known what creates this genomic instability, given the presence of testis antigens in melanoma, it is tempting to speculate that it is caused by a collision of meiotic and mitotic pathways.

Publication types

  • Comment

MeSH terms

  • Genomic Instability*
  • Humans
  • Meiosis
  • Melanoma / genetics*
  • Melanoma / pathology*
  • Mitosis
  • Stem Cells / pathology*