Abstract
The frequencies of the HLA-B*4002 and HLA-A*0206 alleles in patients with aplastic anemia (AA) (n=32; 21.9%) and paroxysmal nocturanl hemoglobinuria (PNH) (n=24; 22.9%), respectively, were significantly different from those in controls (n=371; 8.6%, p<0.002 and 7.7%, p<0.001, respectively), suggesting that each specific allele in AA or PNH may be related to the immunologic pathophysiology of these disorders.
Publication types
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Letter
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Research Support, Non-U.S. Gov't
MeSH terms
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Anemia, Aplastic / genetics
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Anemia, Aplastic / immunology
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Anemia, Aplastic / therapy
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Bone Marrow Transplantation / immunology*
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Gene Frequency
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Hemoglobinuria, Paroxysmal / genetics
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Hemoglobinuria, Paroxysmal / immunology
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Hemoglobinuria, Paroxysmal / therapy
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Histocompatibility Antigens Class I / genetics*
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Humans
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Japan
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Treatment Failure
Substances
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Histocompatibility Antigens Class I