FCP: functional coverage of the proteome by structures

Bioinformatics. 2006 Jul 15;22(14):1792-3. doi: 10.1093/bioinformatics/btl188. Epub 2006 May 16.


Motivation: Tools and resources for translating the remarkable growth witnessed in recent years in the number of protein structures determined experimentally into actual gain in the functional coverage of the proteome are becoming increasingly necessary. We introduce FCP, a publicly accessible web tool dedicated to analyzing the current state and trends of the population of structures within protein families. FCP offers both graphical and quantitative data on the degree of functional coverage of enzymes and nuclear receptors by existing structures, as well as on the bias observed in the distribution of structures along their respective functional classification schemes.

Availability: http://cgl.imim.es/fcp

Contact: jmestres@imim.es.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Algorithms
  • Amino Acid Sequence
  • Database Management Systems
  • Databases, Protein*
  • Information Storage and Retrieval / methods*
  • Internet
  • Molecular Sequence Data
  • Proteome / chemistry*
  • Proteome / classification*
  • Proteome / metabolism
  • Sequence Alignment / methods*
  • Sequence Analysis, Protein / methods*
  • Software*
  • Structure-Activity Relationship
  • User-Computer Interface


  • Proteome