A Novel Antiganglioside Specificity Against Terminal NeuNAc(alfa 2-3)Gal in Acute Bulbar Palsy

J Neuroimmunol. 2006 Jul;176(1-2):219-22. doi: 10.1016/j.jneuroim.2006.04.001. Epub 2006 May 16.

Abstract

We describe a patient with acute oropharyngeal-facial diplegia, tongue palsy and albuminocytological dissociation following upper respiratory tract infection. Electrophysiological abnormalities in blink reflex suggested a brainstem lesion. High titers of anti-GM3, GD1a and GT1b IgG class serum antibodies were initially detected. Absorption studies indicated that antibodies were directed to a common terminal epitope NeuNAc(alfa 2-3)Gal. This novel antiganglioside antibody specificity may play a role in this unusual regional form of acute bulbar palsy of possible central origin. These data are supportive for extending the panel of antiganglioside specificities with anti-GM3.

MeSH terms

  • Acute Disease
  • Antibody Specificity*
  • Bulbar Palsy, Progressive / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • G(M3) Ganglioside / immunology
  • Gangliosides / immunology*
  • Humans
  • Male
  • Middle Aged

Substances

  • G(M3) Ganglioside
  • Gangliosides
  • ganglioside, GD1a
  • trisialoganglioside GT1