Leukaemia of novel gastrointestinal T-lymphocyte population infected with HTLV-I

Lancet. 1991 Jan 12;337(8733):76-7. doi: 10.1016/0140-6736(91)90737-a.


In a 72-year-old man with watery diarrhoea and leukocytosis the proliferation of abnormal cells was studied in specimens obtained by endoscopic biopsy of the gastrointestinal tract. Flow cytometry of leukaemia cells revealed a monoclonal expansion of "double-negative" (CD4-, CD8-) cells bearing T-cell receptor (TCR) alpha beta products. Southern blotting confirmed monoclonal integration of HTLV-I. A novel T-cell subset of double-negative TCR alpha beta cells in the gastrointestinal tract in adult man may be a target for HTLV-I infection.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Antibodies, Monoclonal
  • CD4 Antigens / immunology
  • Colon, Sigmoid / immunology
  • Colon, Sigmoid / pathology
  • DNA, Viral / analysis
  • Deltaretrovirus / genetics
  • HTLV-I Antibodies / analysis*
  • Humans
  • Leukemia-Lymphoma, Adult T-Cell / diagnosis*
  • Leukemia-Lymphoma, Adult T-Cell / etiology
  • Leukemia-Lymphoma, Adult T-Cell / immunology
  • Male


  • Antibodies, Monoclonal
  • CD4 Antigens
  • DNA, Viral
  • HTLV-I Antibodies