Identification of pathological mineral deposits by Raman microscopy

Lancet. 1991 Jan 12;337(8733):77-8. doi: 10.1016/0140-6736(91)90738-b.


Raman microscopy--the analysis of scattered photons after excitation--is well established in non-biological sciences for the identification of crystals. It shows promise in biological (clinical) specimens also, as demonstrated here in studies of synovial fluid, synovium, and gouty tophus, selected for their known content of sodium urate and calcium pyrophosphate crystals.

MeSH terms

  • Aged
  • Calcium Pyrophosphate / analysis*
  • Connective Tissue / chemistry*
  • Crystallization
  • Evaluation Studies as Topic
  • Female
  • Humans
  • Male
  • Middle Aged
  • Reference Standards
  • Spectrum Analysis, Raman* / methods
  • Spectrum Analysis, Raman* / standards
  • Synovial Fluid / chemistry*
  • Uric Acid / analysis*


  • Uric Acid
  • Calcium Pyrophosphate