Corneal ulceration in South East Asia. II: a strategy for the prevention of fungal keratitis at the village level in Burma

Br J Ophthalmol. 2006 Aug;90(8):968-70. doi: 10.1136/bjo.2006.094706. Epub 2006 May 17.

Abstract

Aim: To prove that topical antifungal and antibiotic prophylaxis distributed by grass roots village health workers (VHWs) in Burma is an effective public health intervention for the prevention of post-traumatic microbial keratitis in a population where the majority of ulcers are fungal.

Methods: Three villages in Bago District with a combined population of 16,987 were selected for the study. This defined population was followed prospectively for 12 months by 15 VHWs who were trained to identify post-traumatic corneal abrasions with fluorescein dye and a blue torch and to administer 1% chloramphenicol and 1% clotrimazole ointment three times a day for 3 days to the eyes of individuals who fulfilled the eligibility criteria.

Results: During the 12 month period 273 individuals reported to VHWs with an ocular injury and 126 were found to have a corneal abrasion. All 126 were treated with 1% chloramphenicol and 1% clotrimazole ointment three times a day for 3 days, and all healed without sequelae.

Conclusions: Both fungal and bacterial ulcers that occur following traumatic corneal abrasions can be effectively prevented in a village setting by using relatively simple measures that local volunteer public health workers can easily be taught to employ.

Publication types

  • Evaluation Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Anti-Bacterial Agents / administration & dosage
  • Antifungal Agents / administration & dosage*
  • Child
  • Chloramphenicol / administration & dosage
  • Clotrimazole / administration & dosage
  • Corneal Injuries
  • Corneal Ulcer / microbiology
  • Corneal Ulcer / prevention & control*
  • Delivery of Health Care / organization & administration
  • Developing Countries*
  • Eye Infections, Bacterial / etiology
  • Eye Infections, Bacterial / prevention & control*
  • Eye Infections, Fungal / etiology
  • Eye Infections, Fungal / prevention & control*
  • Female
  • Humans
  • Male
  • Middle Aged
  • Myanmar
  • Ointments
  • Prospective Studies

Substances

  • Anti-Bacterial Agents
  • Antifungal Agents
  • Ointments
  • Chloramphenicol
  • Clotrimazole